CLASSIFICATION OF COAGULANTS 1) Primary coagulants, 2) Coagulant aids 4. PK ! No approved indications. A serine protease inhibitor used to reduce the risk for perioperative blood loss and the need for blood transfusion in high-risk patients during cardiopulmonary bypass for coronary artery bypass graft surgery. Phytonadione is the drug of choice.iii. Human fibrinogn. A Factor VIII replacement therapy used to treat hemophilia A. Canadian brand names are in brackets. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Beroctocog alfa is indicated for the prevention and control of bleeding in patients with hemophilia A or acquired Factor VIII (FVIII) deficiency. When you take a blood thinner, follow directions carefully. Deltasone a. Rosuvastatin is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Agents acting locally eg: Thrombin. ANTICOAGULANTS Drugs that help prevent the clotting (coagulation) of blood Coagulation will occur instantaneously once a blood vessel has been severed Blood begins to solidify to prevent excessive blood loss and to prevent invasive substances from entering the bloodstream. Transfusional agents. Anti-coagulant Prednisone - (prevents/treats inflammation) a. Drugs, that displace warfarin from binding sites on plasma albumin: Chloral hydrate, NSAIDs iv. Anticoagulant Citrate Dextrose Solution, Solution A, U.S.P., (ACD-A), is a sterile, non-pyrogenic solution of citric acid, sodium citrate, and dextrose, in water for injection. Poliglusam, or chitosan, is a linear polysaccharide consisting of D-glucosamine and N-acetyl-D-glucosamine. Hairy Tongue According To Thibodeau Ea et al15: This system of classification is grouped into five sub-categories which includes endogenous, exogenous, drug-related, oral & perioral and miscellaneous. A medication used to control bleeding episodes and prevent bleeding episodes in hemophilia A and B. Anivamersen is under investigation in clinical trial NCT01848106 (A Study to Determine the Efficacy and Safety of REG1 Compared to Bivalirudin in Patients Undergoing PCI). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. 2. Procoagulant drugs are non-transfusional agents that are primarily used when bleeding is the consequence of a specific defect of hemostasis. Coagulant drugs, also called anti-inhibitor coagulant complexes, also help regulate blood coagulation. Anticoagulants 1. Intravenous drug users: thrombosis of the iliofemoral vein is common in this patient group. Coagulant • Haemostasis (arrest of blood loss) and blood coagulation involve complex interactions between the injured vessel wall, platelets and coagulation factors. 6. Anti haemophilic globulin. Drugs, that inhibit warfarin metabolism: - Cimetidine - Imipramine - Cotrimoxazole - Chloramphenicol - Ciprofloxacin - Metronidazole - Amiodarone ii. Pharmaco-metabolomics. They are effective in the arterial circulation, where anticoagulants have little effect. Anticoagulants and antiplatelet drugs are a type of medication that is used to eliminate or reduce the risk of blood clots by helping prevent or break up clots in your blood vessels or heart. Drug Classification. The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification. v$-�� q" [Content_Types].xml �(� Ěˎ� @�����UL�t:��̢�U#���}���I'_��M$bs�'�W��桮� [*9Ki6N��*J�����?����:!Q) �t6���|1��j���-�,]9��b���fJ��W�����Y-�_b ���W$Wҁt#��H�����%��;-�i�~w_�j��uӿ��������K{����ʞ�ZWe.������XF�qd�g{�]�ھ�}����x��~��0eɭ0�h�֎h��S�(�w�T�X�9*_�>H� VW��Y-Jy�S0��_�u��B: zi�N��b����8��E��s8:���5:�:�t�kt���t���oE��E��E�/F�oF��F��F�/G�oG�oG�oG�oG�oG�oG�oG�oG�oG�oG�oG�oG�oG�oG�oG�oG�oG�oG�oG�oG�o� �'�v���Q*���i\|B:��A���[�����1�����Q�����|�~�?�6�`F�;���������h�>��Z��V��> '[&�D�e��ݍ��Lq TOXICITY• Rapid i.v infusion of emulsified Vit. Indication of vit.K.ii. 2. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Classification of drugs. Drugs, that increase warfarin metabolism: - Barbiturates -Rifampin iii. These drugs can be administered to prevent strokes and heart attacks caused by blood clots, or they can be used to treat deep vein thrombosis or pulmonary embolism (blood clot in the lungs). Higher doses produce unresponsiveness tooral anticoagulants for several days. Aminaftone has been investigated for the treatment of Cockett Syndrome, May-Thurner Syndrome, and Iliac Vein Obstruction. Melanin 2. It is used to control bleeding in hemophilia A and B patients with inhibitors. d. Contraindications/ adverse effects 1. Menaquinone is under investigation in clinical trial NCT01533441 (Vitamin K2 Intervention in Patients With Vitamin K Antagonists). It was first patented in 1957 2 and received its initial US approval in 1986. It has the chemical formula Fe4(OH)2(SO4)5. Be able to use cytochrome P450 interaction tables to identify the interactions of other drugs with both R- and S-warfarin. These drugs are prescribed to patients to treat and prevent a variety of diseases and conditions (DVT, pulmonary embolism, blood clot during atrial fibrillation). Menaquinone 6 is under investigation in clinical trial NCT01194778 (Comparison of Efficacy of Different Dosages Vitamin K2).
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