kurtschrute0724. Dobutamine indications. What Is Dobutamin and How Does It Work? Spell. Baxter. [4] It was initially made from isoproterenol. In vitro, dobutamine enantiomers have different agonist and antagonist effects on alpha-1 receptors, as well as beta-2 agonist properties. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Does Dobutamine HCL Vial Interact with other Medications? Onset of action occurs within 2 minutes, although peak pharmacodynamic activity can be delayed up to 10 minutes. Dobutamine is a prescription medication used to improve heart function. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. [5], Dobutamine can be used in cases of congestive heart failure to increase cardiac output. Dobutamine exerts its pharmacological action by selectively stimulating beta-1 adrenergic receptors. Predominant and relatively selective β 1 -receptor stimulation increases the force of myocardial contraction and heart rate, augmenting cardiac output. Side effects and frequent adverse reactions include chest pain, headache, fever, shortness of breath, increased blood pressure. Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-adrenoceptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. [7] The administration of the racemate results in the overall β1 agonism responsible for its activity. Created by. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. STUDY. Dobutamine is prescribed to assist with cardiac output in a person with a failing heart due to heart disease or cardiac surgery. Dobutamine Hydrochloride. Generic Name: dobutamine (doe BUE ta meen)Brand Name: DobutrexDosage Forms: intravenous solution (1 mg/mL-D5%; 12.5 mg/mL; 2 mg/mL-D5%; 4 mg/mL-D5%). Dobutamine has … Dobutamine is administered via continuous IV infusion. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. This hemodynamic profile of dobutamine makes the drug of value in the management of low output cardiac failure. Dopamine, Dobutamine drug cards. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Dobutamine is a catecholamine that is 4-(3-aminobutyl)phenol in which one of the hydrogens attached to the nitrogen is substituted by a 2-(3,4-dihydroxyphenyl)ethyl group. Dobutamine may also be used for purposes not listed in this medication guide. [2] It is available as a generic medication. What is the Therapeutic Class of Dobutamine (Dobutrex) Nursing Pharmacology Considerations? This is not a complete list of side effects and others may occur. Hypotension occurs in almost 40% of all anesthetized patients. [2], Common side effects include a fast heart rate, an irregular heart beat, and inflammation at the site of injection. hypersens. dobutamine. Brand names: Dobutrex Drug class(es): cardiac stressing agents, catecholamines, inotropic agents, vasopressors Dobutamine systemic is used in the treatment of: Heart Failure; Shock Correction of hypotension will likely require the use of positive inotropic drugs like dopamine or dobutamine. to corn (dextrose-containing form) IHSS; caution if HTN; caution if recent MI; caution if arrhythmias; caution if hypovolemia ; caution if hypersens. Since it does not act on dopamine receptors to inhibit the release of norepinephrine (another α1 agonist), dobutamine is less prone to induce hypertension than is dopamine. It is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility, which could be the result of either organic heart disease or cardiac surgical procedures. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. The most dangerous side effect of dobutamine is increased risk of arrhythmia, including fatal arrhythmias. It is used to treat congestive heart failure. It is a positive inotropic drug and increases stroke volume and cardiac out put without significant change in heart rate, peripheral resistance and BP. It improves coronary blood … Drug Class: Beta-1 Selective Sympathomimetic. Dobutamine hydrochloride is a direct-acting inotropic agent whose primary activity results from stimulation of the β receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. [2] The amount of medication needs to be adjusted to the desired effect. You may report side effects to FDA at 1-800-FDA-1088. Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the b-receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. Serious Interactions. Lake Forest, IL; 2014 April. Dobutamine stimulates heart muscle and improves blood flow by helping the heart pump better. You will receive dobutamine in a hospital or clinic setting to quickly treat any serious side effects that occur. It is not known whether dobutamine passes into breast milk or if it could harm a nursing baby. Anon. You should not use dobutamine if you are allergic to it. Drug Class:Anticonvulsants, Others. Usual Adult Dose for Congestive Heart Failure: Initial dose: 0.5 to 1 mcg/kg/min IV infusionMaintenance dose: 2 to 20 mcg/kg/min IV infusionMaximum dose: 40 mcg/kg/min IV infusionComments:-Rate of administration and duration of therapy should be based on blood pressure, heart rate, frequency of ectopic activity, and urine flow; cardiac output, central venous pressure, and pulmonary capillary wedge pressure should also be considered whenever possible.-Concentrations up to 5000 mcg/mL have been administered to humans. It does not cause the release of endogenous norepinephrine, as does dopamine. to drug/class/compon. Lexicomp Online. Dobutamine in 5% dextrose injection prescribing information. View explanations for tiers and restrictions. Medically reviewed by Drugs.com on March 18, 2020. Dobutamine is used short-term to treat cardiac decompensation due to weakened heart muscle. Dopamine vs. Dobutamine. References . Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG). Digoxin is a cardiac glycoside and dobutamine … amitriptyline + amitriptyline. Test. Written by Cerner Multum. Cardiovascular. Dobutamine is used short-term to treat cardiac decompensation due to weakened heart muscle. [citation needed]. Dobutamine M.O.A. to sulfites; Drug Interactions . Hospira. Stimulates Beta1 receptors in the heart. It may also be used in certain types of cardiac stress tests. C01CA07 - dobutamine ; Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. The inotropic activity of dobutamine has previously been attributed to selective stimulation of myocardial beta 1-adrenoceptors. Tell your doctor if you are breast-feeding a baby. If you are using the medicine at home, call your doctor for instructions if you miss a dose of dobutamine. Interaction Characteristics: COMT substrate; hypertensive effects; Avoid/Use Alternative. Used in the treatment of hypotension. What are the possible side effects of Dobutamine? Dobutamine is predominantly a β1-adrenergic agonist, with weak β2 activity, and α1 selective activity, although it is used clinically in cases of cardiogenic shock for its β1 inotropic effect in increasing heart contractility and cardiac output. Select one or more newsletters to continue. Contact the applicable plan provider for the most current information. [2] Onset of effects is generally seen within 2 minutes. Assess heart rate, ECG, and heart sounds, especially during exercise (See Appendices G, H).Report any rhythm disturbances or symptoms of increased arrhythmias, including palpitations, chest discomfort, shortness of breath, fainting, and fatigue/weakness. Determine final volume based on fluid requirements of the patient.-No controlled-trial experience exists beyond 48 hours of repeated boluses and/or continuous infusions.Use: Inotropic support when parenteral therapy is needed in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting from organic heart disease or cardiac surgical procedures. DOBUTAMINE Drug Record Summary; Interactions; Claims; DOBUTAMINE chembl:CHEMBL926 Approved. We comply with the HONcode standard for trustworthy health information -. Find information on Dobutamine (Dobutrex) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Dobutamine. Dobutamine hydrochloride in 5% dextrose injection prescribing information. Dobutamine is a medication used in the treatment of cardiogenic shock and severe heart failure. Hudson, Ohio. It does not cause the release of endogenous norepinephrine, as does dopamine. Buckingham R (ed). A healthcare provider will give you this injection. Dobutamine is usually given after other heart medicines have been tried without success. The above information is provided for general informational and educational purposes only. 114. Dobutamine is a positive inotropic and chronotropic agent. Dobutrex. Onset of effects is generally seen within 2 minutes. [2] It is given by injection into a vein or intraosseous as a continuous infusion. (For additional information see "Dobutamine: Pediatric drug information") Hemodynamic support: Infants, Children, and Adolescents: Continuous IV or intraosseous infusion: Initial: 0.5 to 1 mcg/kg/minute, titrate gradually every few minutes until desired response achieved; usual range: 2 to 20 mcg/kg/minute (PALS [Kleinman 2010]) Dosing: Renal Impairment: Pediatric. Accessed 21/10/2015. Dobutamine is a medication used in the treatment of cardiogenic shock and severe heart failure. Dobutamine is injected into a vein through a catheter. Available for Android and iOS devices. Dobutamine has a positive inotropic effect (increases cardiac output) with very little effect on heart rate. Dobutamine may also be used for purposes not listed in this medication guide. Dobutamine is usually given after other heart medicines have been tried without success. [2], Dobutamine was approved for medical use in the United States in 1978. Used with caution in atrial fibrillation as it has the effect of increasing the atrioventricular (AV) conduction.[6]. [2][3] It may also be used in certain types of cardiac stress tests. It is given by injection into a vein or intraosseous as a continuous infusion. Dobutamine is used short-term to treat cardiac decompensation due to weakened heart muscle. Dobutamine should be used during pregnancy only if clearly needed. Dobutamine is used to help increase cardiac output in a failing heart due to heart disease or cardiac surgery. Compare formulary status to other drugs in the same class. The amount of medication needs to be adjusted to the desired effect. However, recent studies from a number of laboratories indicate that the mechanism of action of dobutamine is substantially more complex. The plasma half-life of dobutamine is about 2 minutes. Digoxin and dobutamine belong to different drug classes. Dobutamine stress testing, particularly combined with echocardiography, is a very widely used tool in cardiological investigation, and its safety continues to be examined in great detail. Alternate Names: DOBUTREX DOBUTAMINE COMPOUND-81929 COMPOUND 81929 Drug Info: Drug Class: cardiotonic agents: Year of Approval: 1978: FDA Approval: 1978: Drug Class: small molecule: Drug Indications: Cardiotonic Agents: Drug Categories: adrenergic alpha-1 receptor agonists: Drug … Call your doctor for medical advice about side effects. [2][4] Use is not recommended in those with idiopathic hypertrophic subaortic stenosis. These help the heart pump better by strengthening the heart muscle. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Read this lesson to learn how it works, which scenarios it would be used in, and what the possible side effects might be. Dobutamine injection is a prescription drug in the drug class of catecholamines. Ronald Tuttle and Jack Mills at Eli Lilly and Company, as a structural analogue of isoprenaline. signs of infection in your catheter--pain, swelling, warmth, redness, oozing, or skin changes where the medicine is injected. Dobutamine may be used alone or with other medications. Find everything you need to know about Dobutamine (Dobutrex), including what it is used for, warnings, reviews, side effects, and interactions. Version: 2.04. amlodipine, lisinopril, metoprolol, furosemide, carvedilol, spironolactone, dexamethasone, methylprednisolone, hydrocortisone, epinephrine. Follow your doctor's instructions about any restrictions on food, beverages, or activity. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 115. Dobutamine stimulates heart muscle and improves blood flow by helping the heart pump better. It is not useful in ischemic heart disease because it increases heart rate and thus increases myocardial oxygen demand. Copyright 1996-2021 Cerner Multum, Inc. Dobutamine is a catecholamine indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of adults with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures. 116. Tell your caregiver right away if you have: shortness of breath (even with mild exertion), swelling, rapid weight gain; a light-headed feeling, like you might pass out; dangerously high blood pressure-severe headache, blurred vision, buzzing in your ears, anxiety, confusion, uneven heartbeats, seizure; or. Dobutamine is a drug used to treat heart failure. Mechanism of Action: Clinically used as a β1 selective adrenergic agonist. Dobutamine is a prescription medicine used to treat the symptoms of cardiac decompensation. Primary side effects include those commonly seen for β1 active sympathomimetics, such as hypertension, angina, arrhythmia, and tachycardia. Individual plans may vary and formulary information changes. Gillies M, Bellomo R, Doolan L et al. Overview. [2] It primarily works by direct stimulation of β1 receptors, which increases the strength of the heart's contractions. [9], InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3, idiopathic hypertrophic subaortic stenosis, "Dobutamine (Dobutrex) Use During Pregnancy", "Dobutamine Hydrochloride Monograph for Professionals", "Dobutamine: development of a new catecholamine to selectively increase cardiac contractility", https://en.wikipedia.org/w/index.php?title=Dobutamine&oldid=998693983, Chemical articles with multiple CAS registry numbers, Articles with unsourced statements from September 2016, Wikipedia medicine articles ready to translate, Creative Commons Attribution-ShareAlike License, This page was last edited on 6 January 2021, at 16:17. While using dobutamine, you may need frequent medical tests. It is unknown if dobutamine passes into breast milk.If a mother requires dobutamine treatment, breastfeeding should be discontinued for the duration of the treatment. Dobutamine belongs to a group of drugs called synthetic catecholamines or inotropic agents. Davis Drug … ATC Classification C01CA07 - dobutamine ; Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. PLAY. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. [3], Dobutamine is used to treat acute but potentially reversible heart failure, such as which occurs during cardiac surgery or in cases of septic or cardiogenic shock, on the basis of its positive inotropic action. Dobutamine, a racemic mixture, stimulates myocardial beta1-adrenergic receptors primarily by the (+) enantiomer and some alpha1 receptor agonism by the (-) enantiomer, resulting in increased contractility and heart rate, and stimulates both beta2- and alpha1-receptors in the vasculature. Access your plan list on any device – mobile or desktop. Match. Determine final volume based on fluid requirements of the patient.-No controlled-trial experience exists beyond 48 hours of repeated boluses and/or continuous infusions.Use: Inotropic support when parenteral therapy is needed in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting from organic heart disease or cardiac surgical procedures. Dobutamine also improves blood flow and relieves symptoms of heart failure. Usual Pediatric Dose for Congestive Heart Failure: Initial dose: 0.5 to 1 mcg/kg/min IV infusionMaintenance dose: 2 to 20 mcg/kg/min IV infusionMaximum dose: 40 mcg/kg/min IV infusionComments:-Certain container systems of this drug may be inappropriate for the dosage requirements of pediatric patients less than 30 kg.-Rate of administration and duration of therapy should be based on systemic blood pressure, heart rate, frequency of ectopic activity urine flow; cardiac output, central venous pressure, and pulmonary capillary wedge pressure should also be considered whenever possible.-Concentrations up to 5000 mcg/mL have been administered to humans. (+)-Dobutamine also has mild β2 agonist activity, which makes it useful as a vasodilator. These medications may interact and cause very harmful effects.
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